Alli weight- loss pill: Does it work? Alli weight- loss pill: Does it work? Is Alli the solution to your weight- loss woes? A Mayo Clinic specialist discusses the effectiveness of Alli, an over- the- counter weight- loss pill. By Mayo Clinic Staff. Donald D. Hensrud, M. D. Alli (pronounced AL- eye) is an over- the- counter drug meant for overweight adults who are struggling to shed excess pounds. With its easy access and weight- loss promises, is Alli your answer to losing weight?
Here, Donald D. Hensrud, M. D., a preventive medicine and nutrition specialist at Mayo Clinic, Rochester, Minnesota, answers common questions about Alli. What is Alli? Alli is the reduced- strength, 6. Xenical), a 1. 20- milligram prescription drug. Xenical is approved for use by people who have a body mass index (BMI) of 3. BMI of 2. 7 to 2. Alli is approved for over- the- counter sale — with some exceptions — to overweight adults 1. Both Alli and Xenical are meant to be used as part of a weight- loss plan that includes a low- calorie, low- fat diet and regular physical activity. What are the concerns with Alli? In 2. 01. 0, the Food and Drug Administration (FDA) published a safety review of orlistat because of rare reports of serious liver injury in people using it. The FDA found no evidence to confirm that orlistat was the cause of the reported liver injuries. However, Alli and Xenical labels were revised because of the reports. Talk to your doctor immediately if you have signs or symptoms that may indicate liver injury: Itching. Loss of appetite. Yellow eyes or skin. Light- colored stool. Brown urine. How does Alli work? Alli promotes weight loss by decreasing the amount of dietary fat absorbed in your intestines. Lipase, an enzyme found in the digestive tract, helps break down dietary fat into smaller components, so it can be used or stored for energy. Alli inhibits the work of lipase. When you take the drug with a meal, about 3. How much weight could I lose using Alli? Alli may help you lose weight, but the weight loss will likely be modest — perhaps just a few pounds more than you would lose with diet and exercise alone. In a 2. 01. 4 review of clinical trials, researchers assessed the effect of weight- loss pills in studies that were at least one year long. People who ate a calorie- restricted diet, exercised regularly and took Alli lost an average of 5. About half the people taking Alli while following a calorie- restricted diet and increasing physical activity lost 5 percent or more of their body weight within a year. Clinically meaningful weight loss — enough weight loss to begin lowering the risk of cardiovascular disease, diabetes and other diseases — is generally defined as 5 percent or more of body weight. Feb. 0. 7, 2. 01. Orlistat: Drug information. Accessed Dec. 3. 0, 2. Food and Drug Administration. Accessed Jan. 1, 2. Weight Loss Supplements Cla - Ldl Cholesterol Education Weight Loss Supplements Cla Ldl Cholesterol Is Good Dash Diet For Lowering Cholesterol. Is conjugated linoleic acid good for weight loss? Find out the facts about CLA including CLA benefits, sources and dosage in this article in this article. FDA drug safety communication: Completed safety review of Xenical/Alli (orlistat) and severe liver injury. Food and Drug Administration. Accessed Dec. 3. 1, 2. Yanovski SZ, et al. Long- term drug treatment for obesity: A systematic and clinical review. Bray GA. Obesity in adults: Drug therapy. Accessed Dec. 3. 0, 2. Alli FAQs: Usage and dosage FAQs. Glaxo. Smith. Kline. Accessed Jan. 1, 2. Alli. Glaxo. Smith. Kline. Accessed Nov. See more In- depth. Over- the- counter weight- loss pills: Do they work? Understanding safety concerns. Limited research also makes it difficult to judge the safety of a weight- loss supplement. And a product isn't necessarily safe simply because it's natural. Ephedra, or ma huang, is an herbal stimulant that was once used in weight- loss products. In 2. 00. 4, the FDA banned ephedra because of possible adverse effects, including mood changes, hypertension, irregular heart rate, stroke, seizures and heart attacks. Bitter orange is a currently available herbal stimulant that is often called an . The active ingredient in bitter orange has chemical properties and actions that are similar to ephedra and may be associated with similar adverse effects. Because of limited research and the use of bitter orange in multi- ingredient supplements, the safety of the product isn't well- understood. Researching before you buy. It's important to do your homework if you're thinking about trying over- the- counter weight- loss pills. General information about many dietary supplements is available at the website of the National Center for Complementary and Alternative Medicines. The Natural Medicines Comprehensive Database summarizes research regarding dietary supplements and herbal products. Although the database is only available by subscription, you may be able to access it through a public library. The following table shows common weight- loss pills and what the research shows about their effectiveness and safety. Product. Claim. Effectiveness. Side effects. SOURCES: JAMA, 2. GLAXOSMITHKLINE CONSUMER HEALTHCARE, 2. NATIONAL INSTITUTES OF HEALTH OFFICE OF DIETARY SUPPLEMENTS, 2. NATURAL MEDICINES COMPREHENSIVE DATABASE, 2. GASTROENTEROLOGY RESEARCH AND PRACTICE, 2. JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION, 2. Alli — nonprescription version of orlistat. Decreases absorption of dietary fat. Modest benefit, less effective than prescription- strength orlistat (Xenical)Loose stools, oily spotting, frequent or hard- to- control bowel movements; reports of rare but serious liver damage. Bitter orange (Citrus aurantium)Increases calories burned, suppresses appetite. Possible modest benefit; very little data. Increased heart rate and blood pressure; reports of anxiety, stroke, irregular heartbeat, heart attack. Chitosan (from exoskeleton of shellfish)Blocks absorption of dietary fat. Probably ineffective; few well- designed studies. Uncommon: upset stomach, nausea, gas, increased stool bulk, constipation. Chromium (essential mineral)Increases lean muscle mass, decreases appetite, increases calories burned. Probably ineffective. Uncommon: watery stools, headache, weakness, insomnia, nausea, vomiting, constipation, dizziness, hives. Conjugated linoleic acid (derived from dairy products and beef)Reduces body fat. Possible modest benefit. Upset stomach, nausea, constipation, loose stools; may decrease good cholesterol and increase bad cholesterol. Green coffee extract. Reduces absorption of sugar (glucose), increases calorie and fat metabolism. Possible modest benefit. Excessive use: anxiety, agitation, insomnia, nausea, irregular heartbeat. Green tea extract. Decreases fat absorption, increases calorie and fat metabolism. Possible slight benefit. Long- term use with high doses: insomnia, agitation, dizzinesss, nausea, vomiting, bloating, gas, diarrhea; reports of liver damage. Guar gum (derived from Indian cluster bean)Blocks absorption of dietary fat, increases feeling of fullness. Probably ineffective. Abdominal pain, gas, diarrhea. Hoodia (succulent plant)Decreases appetite. Probably ineffective; insufficient data. Headache, dizziness, nausea, vomiting; possible increase in heart rate and blood pressure. Raspberry ketone. Increases fat metabolism. Insufficient data. Insufficient data. Including your doctor in your weight- loss plans. If you're considering weight- loss pills, be sure to talk with your doctor, especially if you have health problems, take prescription drugs, or are pregnant or breast- feeding. It's important to get advice on possible interactions with your current use of medicine, vitamins or minerals. Your doctor can offer advice on losing weight, provide support, monitor your progress or refer you to a dietitian. Dec. 1. 9, 2. 01. Dietary supplements for weight loss. National Institutes of Health Office of Dietary Supplements. Accessed Nov. 1. 3, 2. Hensrud DD (expert opinion). Mayo Clinic, Rochester, Minn. Yanovski SZ, et al. Long- term drug treatment for obesity: A systematic and clinical review. Lopez HL, et al. Eight weeks of supplementation with a multi- ingredient weight loss product enhances body composition, reduces hip and waist girth, and increases energy levels in overweight men and women. Journal of the International Society of Sports Nutrition. Bitter orange. Natural Medicines Comprehensive Database. Accessed Nov. 2. 3, 2. Alli. Glaxo. Smith. Kline Consumer Healthcare, L. P. Accessed Nov. 2. Bitter orange. National Center for Complementary and Alternative Medicine. Accessed Nov. 2. 6, 2. Chitosan. Natural Medicines Comprehensive Database. Accessed Nov. 2. 3, 2. Chromium. Natural Medicines Comprehensive Database. Accessed Nov. 2. 3, 2. Conjugated linoleic acid. Natural Medicines Comprehensive Database. Accessed Nov. 2. 3, 2. Onakpoya I, et al. The use of green coffee extract as a weight loss supplement: A systematic review and meta- analysis of randomised clinical trials. Gastroenterology Research and Practice. Green coffee extract. Natural Medicines Comprehensive Database. Accessed Nov. 2. 3, 2. Green tea extract. Natural Medicines Comprehensive Database. Accessed Nov. 2. 3, 2. Guar gum. Natural Medicines Comprehensive Database. Accessed Nov. 2. 3, 2. Hoodia. Natural Medicines Comprehensive Database. Accessed Nov. 2. 3, 2. See more In- depth.
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